20 Best Methyl B12 And Methylfolate [2025]

Are you looking for the best methyl b12 and methylfolate? Based on expert reviews, we ranked them. We've listed our top-ranked picks, including the top-selling methyl b12 and methylfolate.

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1 Superior Source No Shot Vitamin B12 Methylcobalamin (1000 mcg), Methylfolate, B6, Quick Dissolve... Superior Source No Shot Vitamin B12 Methylcobalamin (1000 mcg), Methylfolate, B6, Quick Dissolve...
2 KAL B-6/B-12 Methyl Folate Activmelt, Mixed Berry, White, 60 Count KAL B-6/B-12 Methyl Folate Activmelt, Mixed Berry, White, 60 Count
3 MethylPro B-Complex + 15mg L-Methylfolate (30 Capsules) - Professional Strength B Vitamins for... MethylPro B-Complex + 15mg L-Methylfolate (30 Capsules) - Professional Strength B Vitamins for...
4 Methyl-Life Purest L-Methylfolate 15 mg Pharmaceutical Grade Professional Strength Active Folate - 3... Methyl-Life Purest L-Methylfolate 15 mg Pharmaceutical Grade Professional Strength Active Folate -...
5 Superior Source No Shot Methylfolate B12 2000mcg P5P Tablets, 60 Count Superior Source No Shot Methylfolate B12 2000mcg P5P Tablets, 60 Count
6 MethylPro B-Complex + 5mg L-Methylfolate (30 Capsules) - Professional Strength B Vitamins for... MethylPro B-Complex + 5mg L-Methylfolate (30 Capsules) - Professional Strength B Vitamins for...
7 Designs for Health B-Supreme - Vitamin B Complex with B1, B2, B3, Biotin, B6, Active Folate... Designs for Health B-Supreme - Vitamin B Complex with B1, B2, B3, Biotin, B6, Active Folate...
8 Vitamin B Supplements Complex with Vitamins B6 20mg, D3 1000IU, Magnesium 260mg, Methyl B12 1000mcg,... Vitamin B Supplements Complex with Vitamins B6 20mg, D3 1000IU, Magnesium 260mg, Methyl B12...
9 Designs for Health Ultra B12-Folate - Methyl Folate (5-MTHF) + Vitamin B12 (Adenosylcobalamin +... Designs for Health Ultra B12-Folate - Methyl Folate (5-MTHF) + Vitamin B12 (Adenosylcobalamin +...
10 MethylPro B-Complex + 5mg L-Methylfolate (90 Capsules) - Professional Strength B Vitamins for... MethylPro B-Complex + 5mg L-Methylfolate (90 Capsules) - Professional Strength B Vitamins for...
11 Thorne Basic B-Complex - Tissue-Ready Vitamin B Complex Supplement with Choline - Supports Cellular... Thorne Basic B-Complex - Tissue-Ready Vitamin B Complex Supplement with Choline - Supports...
12 Jarrow Formulas Methyl B-12 & Methyl Folate - 60 Chewable Tablets, Cherry - Bioactive Vitamin B12 &... Jarrow Formulas Methyl B-12 & Methyl Folate - 60 Chewable Tablets, Cherry - Bioactive Vitamin B12...
13 Jarrow Formulas Methyl B-12 & Methyl Folate - 100 Chewable Tablets, Lemon - Bioactive Vitamin B12 &... Jarrow Formulas Methyl B-12 & Methyl Folate - 100 Chewable Tablets, Lemon - Bioactive Vitamin B12...
14 L Methyl Folate 15mg Plus Methyl B12 Cofactor - Professional Strength, Active 5-MTHF Form - Supports... L Methyl Folate 15mg Plus Methyl B12 Cofactor - Professional Strength, Active 5-MTHF Form -...
15 Double Strength & Most Bioactive Methyl Folate! Uniquely Formulated with Highest Pharmaceutical... Double Strength & Most Bioactive Methyl Folate! Uniquely Formulated with Highest Pharmaceutical...
16 Douglas Laboratories - Methyl B12 Plus - Supports Blood Cell Production, Nervous System, and... Douglas Laboratories - Methyl B12 Plus - Supports Blood Cell Production, Nervous System, and...
17 MD. Life L-Methylfolate 5 mg - Active Folate 5 Mthfr Support Supplement Professional Strength Methyl... MD. Life L-Methylfolate 5 mg - Active Folate 5 Mthfr Support Supplement Professional Strength...
18 Vital Nutrients - Vitamin B12 / Methyl Folate - Supports Healthy Brain Cell Function - 100... Vital Nutrients - Vitamin B12 / Methyl Folate - Supports Healthy Brain Cell Function - 100...
19 Seeking Health Active B12 with L-5-MTHF, 60 Lozenges, Vitamin B12 Supplement, Supports Cellular... Seeking Health Active B12 with L-5-MTHF, 60 Lozenges, Vitamin B12 Supplement, Supports Cellular...
20 Jarrow Formulas Methyl Folate 400 mcg - 60 Veggie Caps - Highly Biologically Active Form of Folate -... Jarrow Formulas Methyl Folate 400 mcg - 60 Veggie Caps - Highly Biologically Active Form of Folate...
Bestseller No. 1
Superior Source No Shot Vitamin B12 Methylcobalamin (1000 mcg), Methylfolate, B6, Quick Dissolve...
  • FEEL MORE ENERGIZED Vitamin B12 plays an important role in the body's energy production and protection of the nervous system. Methylcobalamin, is the...
  • JUST PURE INGREDIENTS – Non-GMO, gluten-free, preservative free, sugar free, dye free; no fillers, no additives, no excipients, no Magnesium...
  • MICROLINGUAL VITAMINS – Melts that dissolve instantly with no pills to swallow. Superior Source pioneered the world's best delivery system of...
  • GMP CERTIFIED QUALITY - We test all incoming raw materials for the active ingredients, heavy metals, GMOs, and microbial contamination through a...
  • SUPERIOR SOURCE, THE COMPANY THAT CARES - Creating pure MicroLingual vitamins since 1998 in our family owned manufacturing facility. We are a company...
SaleBestseller No. 2
KAL B-6/B-12 Methyl Folate Activmelt, Mixed Berry, White, 60 Count
  • To be taken under the medical supervision of your healthcare professional.
  • Simply pop one ActivMelt micro tablet on the tongue every day.
  • Pregnant or lactating women have an increased need for folate and may take one micro tablet up to twice daily.
  • Folate consumption must not exceed 250% or 1000 mcg of the recommended daily value
  • To be stored in a dry, cool place.
Bestseller No. 3
MethylPro B-Complex + 15mg L-Methylfolate (30 Capsules) - Professional Strength B Vitamins for...
  • #1 In Professional Strength Methylfolate - MethylPro is the leading nutraceutical line featuring l-methylfolate, the most active, advanced form of...
  • Doctor Developed B Complex - Eliminate the need for extra B-vitamin supplements. Doctors most familiar with L-Methylfolate have developed this...
  • 100X More Soluble - Feel the difference of the most advanced methylfolate on the market. Quatrefolic, the 4th generation folate, is 100x more water...
  • Brain & Cardiovascular Support - L-Methylfolate is important for the production of neurotransmitters involved in concentration, sleep, hormones, mood...
  • No Fillers - MethylPro never uses fillers or excipients like bulking agents, glues, or binders. This product is free of gluten, dairy, eggs, and nuts....
Bestseller No. 4
Methyl-Life Purest L-Methylfolate 15 mg Pharmaceutical Grade Professional Strength Active Folate - 3...
  • THE PUREST ACTIVE FOLATE – Up to 70% of the population may have trouble converting & absorbing folic acid. Methyl-Life carries the purest form of...
  • THERAPEUTIC STRENGTH – Lots of methylfolate products have lower doses (400-1 000 mcg). Methyl-Life creates professional dosage levels from 2 500-15...
  • MOOD & COGNITIVE SUPPORT – The only folate form to cross the blood-brain barrier. It helps with neurotransmitter production (i.e. serotonin) which...
  • CARDIOVASCULAR & NERVE SUPPORT – May help support healthy homocysteine levels which promote heart health and peripheral nerve function.*
  • EASY CHEWABLE – Methyl-Life creates tiny chewable tablets that are super easy for anyone to take. No dyes allergens or extra fillers in the formula....
Bestseller No. 5
Superior Source No Shot Methylfolate B12 2000mcg P5P Tablets, 60 Count
  • Tablets go to work fast, under the tongue
  • They efficiently provide your body with the nutrients you need right now
  • MicroLingual tablets dissolve immediately under the tongue heading straight into the body.
  • During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when...
Bestseller No. 6
MethylPro B-Complex + 5mg L-Methylfolate (30 Capsules) - Professional Strength B Vitamins for...
  • #1 In Professional Strength Methylfolate - MethylPro is the leading nutraceutical line featuring l-methylfolate, the most active, advanced form of...
  • Doctor Developed B Complex - Eliminate the need for extra B-vitamin supplements. Doctors most familiar with L-Methylfolate have developed this...
  • 100X More Soluble - Feel the difference of the most advanced methylfolate on the market. Quatrefolic, the 4th generation folate, is 100x more water...
  • Brain & Cardiovascular Support - L-Methylfolate is important for the production of neurotransmitters involved in concentration, sleep, hormones, mood...
  • No Fillers - MethylPro never uses fillers or excipients like bulking agents, glues, or binders. This product is free of gluten, dairy, eggs, and nuts....
Bestseller No. 7
Designs for Health B-Supreme - Vitamin B Complex with B1, B2, B3, Biotin, B6, Active Folate...
  • Pre-Activated For Superior Absorption - This very powerful B vitamin combination supplies most of the B vitamins in their coenzymated forms, so they...
  • Methyl Folate & Methyl B12 - Includes Quatrefolic folate, which has demonstrated high bioavailability, solubility, and long-lasting stability and....
  • Synergistic Formula - TMG and choline are included to support methylation.*
  • Vegan & Non-GMO - This product is Vegetarian and Vegan-Friendly. Made without GMOs, Gluten, Dairy, or Soy. Tinted glass bottles offer a barrier...
  • Over 50,000 Doctors Agree - Designs for Health is the physician's choice for top quality professional strength supplements since 1989. Our "Science...
Bestseller No. 8
Vitamin B Supplements Complex with Vitamins B6 20mg, D3 1000IU, Magnesium 260mg, Methyl B12 1000mcg,...
  • Try Age Immune Doctor Formulated B Complex Supplements in easy to swallow capsules.
  • Folic Acid as Methyl Folate, B6, Methylated B12, Vitamin D & Magnesium Bisglycinate complex supports MTHFR gene expression.
  • With Vitamin D3 1000IU.
  • Free of Magnesium Stearate, Silica and other lubricants. Does not contain yeast and artificial fillers, flavors and preservatives. Made with Love and...
  • Supports Energy, Focus, Stamina, Mood, Clarity and Concentration.
Bestseller No. 9
Designs for Health Ultra B12-Folate - Methyl Folate (5-MTHF) + Vitamin B12 (Adenosylcobalamin +...
  • POWERFUL TEAMWORK - Folate & B12 work synergistically, promoting methylation and helping to promote balanced concentrations of homocysteine. Ideal for...
  • SUPERIOR FOLATE - This proprietary NatureFolate blend contains safe, naturally-occurring folates in their active 5-MTHF form.*
  • ACTIVE FORMS OF B12 - The premium B12 in this product comes from equal amounts of adenosylcobalamin and methylcobalamin. With 2000 mg per capsule.
  • HIGHER STANDARDS. BETTER RESULTS - Designs for Health maintains a strict, no-compromises approach to quality raw material selection. We never cut...
  • OVER 50,000 DOCTORS AGREE - Designs for Health is the physician's choice for top quality professional strength supplements since 1989. Our "Science...
Bestseller No. 10
MethylPro B-Complex + 5mg L-Methylfolate (90 Capsules) - Professional Strength B Vitamins for...
  • #1 In Professional Strength Methylfolate - MethylPro is the leading nutraceutical line featuring l-methylfolate, the most active, advanced form of...
  • Doctor Developed B Complex - Eliminate the need for extra B-vitamin supplements. Doctors most familiar with L-Methylfolate have developed this...
  • 100X More Soluble - Feel the difference of the most advanced methylfolate on the market. Quatrefolic, the 4th generation folate, is 100x more water...
  • Brain & Cardiovascular Support - L-Methylfolate is important for the production of neurotransmitters involved in concentration, sleep, hormones, mood...
  • No Fillers - MethylPro never uses fillers or excipients like bulking agents, glues, or binders. This product is free of gluten, dairy, eggs, and nuts....
Bestseller No. 11
Thorne Basic B-Complex - Tissue-Ready Vitamin B Complex Supplement with Choline - Supports Cellular...
  • Nervous System: Promotes an optimally functioning nervous system and healthy nerve cells
  • Cellular Energy: B vitamins promote cellular energy production by supporting the conversion of carbohydrates into energy, as well as the metabolism of...
  • Complete Formula: An optimal balance of eight B vitamins, plus choline, in their active form to enhance absorption in the body
  • Free From: Doesn't contain gluten, eggs, tree nuts, peanuts, dairy, soy, fish, or shellfish
  • Trusted: Thorne is chosen by champions and trusted by 100+ pro teams. Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on...
SaleBestseller No. 12
Jarrow Formulas Methyl B-12 & Methyl Folate - 60 Chewable Tablets, Cherry - Bioactive Vitamin B12 &...
  • Bioactive B Vitamins - Methyl B-12 & Methyl Folate provides methylcobalamin (methyl B-12) & methyl folate, which are the biologically active forms of...
  • Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product...
  • Full-Body Benefits - This Jarrow Formulas supplement combines the active forms of these vitamins to support energy production, brain function, DNA &...
  • Homocysteine Metabolism - Methyl B-12 and methyl folate facilitate the metabolism of homocysteine into methionine, while P5P facilitates the...
  • Convenient Chewable Tablet - Each cherry-flavored chewable tablet delivers 2.5 mg of vitamin B6, 1360 mcg of folate, and 5000 mcg of vitamin B12. Our...
SaleBestseller No. 13
Jarrow Formulas Methyl B-12 & Methyl Folate - 100 Chewable Tablets, Lemon - Bioactive Vitamin B12 &...
  • Bioactive B Vitamins - Methyl B-12 & Methyl Folate provides methylcobalamin (methyl B-12) & methyl folate, which are the biologically active forms of...
  • Energy Support Benefits - This Jarrow Formulas supplement helps to support cellular energy metabolism & neurotransmitter synthesis.
  • Homocysteine Metabolism - The unique combination of these B vitamins support the recycling of homocysteine to methionine to support cardiovascular...
  • Convenient Chewable Tablet - Each lemon-flavored chewable tablet delivers 1.5 mg of vitamin B6, 400 mcg of methyl folate, and 1000 mcg of vitamin B12....
  • Superior Science, Smarter Formulas - Informed by strong scientific research, Jarrow Formulas products are carefully crafted to ensure you get the...
Bestseller No. 14
L Methyl Folate 15mg Plus Methyl B12 Cofactor - Professional Strength, Active 5-MTHF Form - Supports...
  • PROFESSIONAL STRENGTH: Provides clinically validated dosage of 15mg L Methyl folate in the 5-MTHF calcium salt form. This is the most active form of...
  • ESSENTIAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships. Both are crucial in the body's methylation...
  • ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is...
  • BRAIN, MOOD & ENERGY SUPPORT: Essential to neurotransmitters production involved in concentration, sleep, energy, hormones & mood.*
  • CARDIOVASCULAR, NITRIC OXIDE & NERVE SUPPORT: Supports heart health and nerve function by supporting healthy homocysteine levels and nitric oxide...
Bestseller No. 15
Double Strength & Most Bioactive Methyl Folate! Uniquely Formulated with Highest Pharmaceutical...
  • ♥ Lab tested and most powerful Methylfolate supplying essential support for DNA and neurotransmitter synthesis along with amino acid metabolism.
  • ♥ Developed as most optimally absorbed and bioavailable 5-MTHF
  • ♥ Delivering key supplementation for brain, heart and nerve function, as well as support for women who are pregnant and overall health
  • ♥ Suitable for people who are diagnosed with MTHFR mutation
  • ♥ To ensure purity and safety, our products are manufactured in a fully GMP-certified facility. Our product is third party tested to assure the...
Bestseller No. 16
Douglas Laboratories - Methyl B12 Plus - Supports Blood Cell Production, Nervous System, and...
  • Energy Support: As coenzymes, the B vitamins play an important role in proper energy production, including the metabolism of lipids, carbohydrates,...
  • Unique B Vitamins: Methylfolate and methylcobalamin are the predominant forms of B vitamins commonly found in cells that do not require additional...
  • Vitamins/Minerals/Amino Acids: Dietary supplement formulated to provide beneficial support in filling important nutrient gaps.*
  • Our uncompromising operational practices at our state-of-the-art manufacturing facilities surpass GMP standards and manufacturing regulations. All of...
  • For 65 years, Douglas Laboratories has been dedicated to meeting the needs of healthcare professionals. As a globally recognized leader in the...
Bestseller No. 17
MD. Life L-Methylfolate 5 mg - Active Folate 5 Mthfr Support Supplement Professional Strength Methyl...
  • ACTIVE FOLATE THAT WORKS - This L methylfolate 5mg formula contains the ingredients necessary for your body to properly utilize folic acid, also known...
  • SYNTHESIS AND REPAIR* - Methylfolate 5 mg, the most active form, is essential in the production and maintenance of new cells.*
  • THIRD PARTY TESTED FOR PURITY - All our brain supplements undergo extensive third -party testing to maintain the highest level of quality and purity...
  • MOOD & BRAIN SUPPORT* – MD Life’s Methyl folate 5mg is a great choice for mood support. Sleep, concentration, energy, mood stability and hormone...
SaleBestseller No. 18
Vital Nutrients - Vitamin B12 / Methyl Folate - Supports Healthy Brain Cell Function - 100...
  • GI Health: Vitamin B12 & Folate work together to support the health of the gastrointestinal tract
  • Nerve Support Formula: Methylated forms of B12 & folate are considered to be the most bioavailable
  • Prenatal Vitamins: Folate as L-5-MTHF 800mcg may reduce the risk of neural tube birth defects
  • Quality, Purity & Potency: No coatings or binders, gluten-free, dairy-free, soy-free & sugar-free
  • Vital Nutrients: Committed to making high-quality supplements that support health & vitality
Bestseller No. 19
Seeking Health Active B12 with L-5-MTHF, 60 Lozenges, Vitamin B12 Supplement, Supports Cellular...
  • HEALTHY ENERGY LEVELS: Active B12 with L-5-MTHF by Seeking Health provides 1,360 mcg DFE (800 mcg) of pure non-racemic L-methylfolate in an...
  • HEALTHY MOOD AND FOCUS: Experience a supported healthy mood, focus, energy, and clarity. Note: This is a situational supplement; only take it when you...
  • IDEAL FOR MTHFR GENE MUTATION: By taking this combination of methylated nutrients—methylfolate and methylcobalamin—in Active Vitamin B12 with...
  • LOZENGE: This easy-to-take and great-tasting lozenge isn’t your typical daily supplement. You should take it on an as-needed basis, or as directed...
  • CONSISTENT QUALITY: At Seeking Health, every ingredient is carefully sourced, researched, and tested. Each meets strict specifications for...
SaleBestseller No. 20
Jarrow Formulas Methyl Folate 400 mcg - 60 Veggie Caps - Highly Biologically Active Form of Folate -...
  • Methyl Folate - Jarrow Formulas Methyl Folate is a highly biologically active form of folate. Due to the body’s limited ability to transform...
  • Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product...
  • Quatrefolic - Featuring 4th generation development in folate delivery, our patent-pending technology formula features increased stability and...
  • Benefits - Healthful diets with adequate folate may reduce the risk of having a child with a brain or spinal cord birth defect.*
  • Convenient Veggie Capsules - Each veggie capsule delivers 400 micrograms (mcg) of methyl folate. Take 1 capsule per day, with or without a meal, or as...

Having trouble finding a great methyl b12 and methylfolate?

This problem is well understood by us because we have gone through the entire methyl b12 and methylfolate research process ourselves, which is why we have put together a comprehensive list of the best methyl b12 and methylfolates available in the market today.

After hours of searching and using all the models on the market, we have found the best methyl b12 and methylfolate for 2023. See our ranking below!

How Do You Buy The Best Methyl B12 And Methylfolate?

Do you get stressed out thinking about shopping for a great methyl b12 and methylfolate? Do doubts keep creeping into your mind?

We understand, because we’ve already gone through the whole process of researching methyl b12 and methylfolate, which is why we have assembled a comprehensive list of the greatest methyl b12 and methylfolate available in the current market. We’ve also come up with a list of questions that you probably have yourself.

John Harvards has done the best we can with our thoughts and recommendations, but it’s still crucial that you do thorough research on your own for methyl b12 and methylfolate that you consider buying. Your questions might include the following:

  • Is it worth buying an methyl b12 and methylfolate?
  • What benefits are there with buying an methyl b12 and methylfolate?
  • What factors deserve consideration when shopping for an effective methyl b12 and methylfolate?
  • Why is it crucial to invest in any methyl b12 and methylfolate, much less the best one?
  • Which methyl b12 and methylfolate are good in the current market?
  • Where can you find information like this about methyl b12 and methylfolate?

We’re convinced that you likely have far more questions than just these regarding methyl b12 and methylfolate, and the only real way to satisfy your need for knowledge is to get information from as many reputable online sources as you possibly can.

Potential sources can include buying guides for methyl b12 and methylfolate, rating websites, word-of-mouth testimonials, online forums, and product reviews. Thorough and mindful research is crucial to making sure you get your hands on the best-possible methyl b12 and methylfolate. Make sure that you are only using trustworthy and credible websites and sources.

John Harvards provides an methyl b12 and methylfolate buying guide, and the information is totally objective and authentic. We employ both AI and big data in proofreading the collected information.

How did we create this buying guide? We did it using a custom-created selection of algorithms that lets us manifest a top-10 list of the best available methyl b12 and methylfolate currently available on the market.

This technology we use to assemble our list depends on a variety of factors, including but not limited to the following:

  1. Brand Value: Every brand of methyl b12 and methylfolate has a value all its own. Most brands offer some sort of unique selling proposition that’s supposed to bring something different to the table than their competitors.
  2. Features: What bells and whistles matter for an methyl b12 and methylfolate?
  3. Specifications: How powerful they are can be measured.
  4. Product Value: This simply is how much bang for the buck you get from your methyl b12 and methylfolate.
  5. Customer Ratings: Number ratings grade methyl b12 and methylfolate objectively.
  6. Customer Reviews: Closely related to ratings, these paragraphs give you first-hand and detailed information from real-world users about their methyl b12 and methylfolate.
  7. Product Quality: You don’t always get what you pay for with an methyl b12 and methylfolate, sometimes less, and sometimes more.
  8. Product Reliability: How sturdy and durable an methyl b12 and methylfolate is should be an indication of how long it will work out for you.

John Harvards always remembers that maintaining methyl b12 and methylfolate information to stay current is a top priority, which is why we are constantly updating our websites. Learn more about us using online sources.

If you think that anything we present here regarding methyl b12 and methylfolate is irrelevant, incorrect, misleading, or erroneous, then please let us know promptly!

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FAQ:

Q: How to differentiate between a B12 and a folate deficiency?

A: Symptoms of vitamin B12 or folate deficiency. Vitamin B12 and folate perform several important functions in the body,including keeping the nervous system healthy. When to see your GP. … Causes of a vitamin B12 or folate deficiency. … Treating vitamin B12 or folate deficiency anaemia. … Complications of vitamin B12 or folate deficiency anaemia. …

Q: What are normal B12 and folate levels?

A: What are normal b12 and folate levels? But a normal level of vitamin B12 in your bloodstream is generally between 190 and 950 picograms per milliliter (pg/mL). In some cases, your doctor may also test for your folate level because low folate can cause signs and symptoms similar to low B12. What is a good folate level?

Q: When to take vitamin B12?

A: Dizziness Headache Nausea Diarrhoea Skin irritation Fatigue A tingling sensation in hands or feet.

Q: Does vitamin B12 interfere with metformin?

A: The mechanism for low B12 with metformin, I don’t think it has been completely sorted out, but it appears to be a problem with absorption. It’s not related to intrinsic factors—so the classic pernicious anemia that we all learned about in medical school, that’s not really the mechanism, but there seems to be something about the effect of metformin in the gut that impairs absorption.