20 Best Equate Extra Strength Acetaminophen [2025]

Are you looking for the best equate extra strength acetaminophen? Based on expert reviews, we ranked them. We've listed our top-ranked picks, including the top-selling equate extra strength acetaminophen.

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1 Equate Extra Strength Headache Relief Caplets, 200ct, Compare to Excedrin Extra Strength Caplets Equate Extra Strength Headache Relief Caplets, 200ct, Compare to Excedrin Extra Strength Caplets
2 Equate Pain Reliever PM Extra Strength Gel Caps Nighttime Sleep Aid/Pain Reliever, 80 Count Equate Pain Reliever PM Extra Strength Gel Caps Nighttime Sleep Aid/Pain Reliever, 80 Count
3 Equate - Pain Reliever PM Nighttime Sleep Aid, Extra Strength, Acetaminophen 20 Gelcaps Equate - Pain Reliever PM Nighttime Sleep Aid, Extra Strength, Acetaminophen 20 Gelcaps
4 Pack of 6 - Equate Extra Strength Acetaminophen Rapid Release Gelcaps, 500 mg, 100 Ct Pack of 6 - Equate Extra Strength Acetaminophen Rapid Release Gelcaps, 500 mg, 100 Ct
5 Equate Extra Strength Acetaminophen Twin-Pack 500mg, 500 tabs Equate Extra Strength Acetaminophen Twin-Pack 500mg, 500 tabs
6 Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count
7 Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 200 Count Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 200 Count
8 Amazon Basic Care Naproxen Sodium Tablets, 300 Count Amazon Basic Care Naproxen Sodium Tablets, 300 Count
9 Amazon Basic Care Ibuprofen Tablets, Fever Reducer and Pain Relief from Body Aches, Headache,... Amazon Basic Care Ibuprofen Tablets, Fever Reducer and Pain Relief from Body Aches, Headache,...
10 GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count
11 Equate - Arthritis Pain Reliever, Extended Release, Acetaminophen 650 Mg, 100-Count Equate - Arthritis Pain Reliever, Extended Release, Acetaminophen 650 Mg, 100-Count
12 Rite Aid Extra Strength 500 mg Acetaminophen Pain Relief, Rapid Release Gelcaps - 225 Count | Pain... Rite Aid Extra Strength 500 mg Acetaminophen Pain Relief, Rapid Release Gelcaps - 225 Count |...
13 Equate Pain Reliever PM Extra Strength Nighttime Sleep Aid/Pain Reliever, 100 Count Equate Pain Reliever PM Extra Strength Nighttime Sleep Aid/Pain Reliever, 100 Count
14 GenCare - Extra Strength Headache Relief Acetaminophen with Aspirin (NSAID) & Caffeine (300 Caplets)... GenCare - Extra Strength Headache Relief Acetaminophen with Aspirin (NSAID) & Caffeine (300...
15 Rite Aid Extra Strength 500 mg Acetaminophen Pain Relief, Rapid Release Gelcaps - 150 Count | Pain... Rite Aid Extra Strength 500 mg Acetaminophen Pain Relief, Rapid Release Gelcaps - 150 Count |...
16 ValuMeds Extra Strength Headache Relief Caplets (300-Count) | Nonsteroidal Anti-Inflammatory Pain... ValuMeds Extra Strength Headache Relief Caplets (300-Count) | Nonsteroidal Anti-Inflammatory Pain...
17 Amazon Basic Care Naproxen Sodium Tablets, 220 mg, 100 Count Amazon Basic Care Naproxen Sodium Tablets, 220 mg, 100 Count
SaleBestseller No. 1
Equate Extra Strength Headache Relief Caplets, 200ct, Compare to Excedrin Extra Strength Caplets
  • Compare to Excedrin Extra Strength Caplets Active Ingredients.
  • Acetaminophen, Aspirin (NSAID) and Caffeine.
  • Pain Reliever/Pain Reliever Aid.
  • 200 Caplets.
Bestseller No. 2
Equate Pain Reliever PM Extra Strength Gel Caps Nighttime Sleep Aid/Pain Reliever, 80 Count
  • Compare to extra strength Tylenol pm active ingredients
  • Pain reliever/nighttime sleep aid
  • Acetaminophen/diphenhydramine hcl
  • Nonhabit forming
SaleBestseller No. 3
Equate - Pain Reliever PM Nighttime Sleep Aid, Extra Strength, Acetaminophen 20 Gelcaps
  • Compare to Extra Strength Tylenol PM Active Ingredients.
  • Pain Reliever/Nigthtime Sleep Aid.
  • Acetaminophen/Diphenhydramine HCl.
  • Non-Habit Forming.
  • 20 Gelcaps. Rapid Release.
Bestseller No. 4
Pack of 6 - Equate Extra Strength Acetaminophen Rapid Release Gelcaps, 500 mg, 100 Ct
  • Over-the-counter pain reliever
  • Compare to extra-strength Tylenol active ingredient
  • Aspirin free
  • Rapid-release formula
  • Extra strength pain reliever and
Bestseller No. 5
Equate Extra Strength Acetaminophen Twin-Pack 500mg, 500 tabs
  • Contains no aspirin
  • Large TwinPack includes TWO bottles, each containing 250 500mg caplets
SaleBestseller No. 6
Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count
  • ACTIVE INGREDIENT: Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg active ingredient is acetaminophen 650 mg,. Compare to the active...
  • PURPOSE: Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg is a pain reliever and fever reducer that can be used for the temporary...
  • TEMPORARY PAIN RELIEF: This product may also be used to temporarily relieve other minor aches and pains due to: muscular aches, backache, premenstrual...
  • ASPIRIN FREE, GLUTEN FREE: Extended release caplets (capsule-shaped tablets) each provide 650 mg of acetaminophen, pain reliever and fever reducer,...
  • PUSH & TURN CAP: The container has a child-resistant cap. This product is a pain reliever and fever reducer for adults. Under 18 years of age, ask a...
Bestseller No. 7
Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 200 Count
  • ACTIVE INGREDIENT: Amazon Basic Care Extra Strength Pain Relief's active ingredient is Acetaminophen, 500 mg, which compares to the active ingredient...
  • Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, temporarily relieves minor aches and pains due to: the common cold,...
  • USE: Acetaminophen may be used as a pain reliever and fever reducer for adults and children 12 years and over
  • PAIN: Pain may begin with an injury or illness, but could also originate with anything from a bad mattress to arthritis
  • ACUTE PAIN: Acute pain acts as an alarm such as with a bee sting or stubbing your toe and can last for a few moments or for longer
SaleBestseller No. 8
Amazon Basic Care Naproxen Sodium Tablets, 300 Count
  • ACTIVE INGREDIENT: This pain reliever and fever reducer contains naproxen sodium 220 mg, a nonsteroidal anti-inflammatory drug (NSAID); compare to the...
  • STRENGTH TO LAST 12 HOURS: Pain reliever and fever reduction for up to 12 hours so you can get through the day
  • ACHES AND PAINS: Temporarily relieves minor aches and pains due to minor pain of arthritis, muscular aches, backache, menstrual cramps, headache,...
  • ALL DAY RELIEF: Amazon Basic Care Naproxen Sodium Tablets 220 mg is a pain reliever and fever reducer for adults and children age 12 years and over
  • CAPSULE-SHAPED TABLETS: This 12 hour pain reliever and fever reducer comes in a capsule-shaped tablet; this product is gluten free
Bestseller No. 9
Amazon Basic Care Ibuprofen Tablets, Fever Reducer and Pain Relief from Body Aches, Headache,...
  • ACTIVE INGREDIENT: This product contains ibuprofen 200 mg, a pain reliever and fever reducer (NSAID); compare to the active ingredient in Advil...
  • PAIN RELIEVER AND FEVER REDUCER: Proven pain relief without a prescription for tough pain such as muscular aches, minor arthritis pain, toothache,...
  • STRONG RELIEF: Amazon Basic Care Ibuprofen Tablets 200 mg are strong on tough pain to help you get the relief you need to keep going; no prescription...
  • EFFECTIVE: When pain tries to take over, turn to the proven pain relief of coated Amazon Basic Care Ibuprofen Tablets 200 mg; use for adults and...
  • IBUPROFEN is the number one doctor recommended back pain OTC active ingredient (of U.S. physicians surveyed by an independent market research firm)
Bestseller No. 10
GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count
  • ACTIVE INGREDIENT: GoodSense Extra Strength Pain Relief's active ingredient is Acetaminophen, 500 mg, which compares to the active ingredient of Extra...
  • GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, temporarily relieves minor aches and pains due to: the common cold, headache,...
  • USE: Acetaminophen may be used as a pain reliever and fever reducer for adults and children 12 years and over
  • PAIN: Pain may begin with an injury or illness, but could also originate with anything from a bad mattress to arthritis
  • ACUTE PAIN: Acute pain acts as an alarm such as with a bee sting or stubbing your toe and can last for a few moments or for longer
SaleBestseller No. 11
Equate - Arthritis Pain Reliever, Extended Release, Acetaminophen 650 Mg, 100-Count
  • Compare to Tylenol Arthritis Pain active ingredients
  • Extended-Release Tablets. Lasts Up to 8 Hours
  • Acetaminophen 650 mg
  • For the temporary Relief of Minor Arthritis Pain
SaleBestseller No. 12
Rite Aid Extra Strength 500 mg Acetaminophen Pain Relief, Rapid Release Gelcaps - 225 Count | Pain...
  • PAIN RELIEVER & FEVER REDUCER: Rite Aid Extra Strength Acetaminophen Rapid Release Gelcaps reduce fevers temporarily while offering minor headache...
  • EXTRA STRENGTH: Compare Rite Aid’s Extra Strength Acetaminophen Rapid Release Gels to the active ingredient in top brands. Get all the benefits of...
  • EASY-OPEN BOTTLE: When you need pain relief, you want a quick and easy bottle to open. Rite Aid Acetaminophen comes in an easy-open bottle that’s...
  • NO ASPIRIN: Each gelcap contains 500 mg of pain relieving, fever reducing acetaminophen without any aspirin. This aspirin-free arthritis pain relief,...
  • TRUSTED BRAND SINCE 1962: We hope you continue to choose Rite Aid first for your everyday health and wellness needs. Our mission is to improve the...
SaleBestseller No. 13
Equate Pain Reliever PM Extra Strength Nighttime Sleep Aid/Pain Reliever, 100 Count
  • Compare to Extra Strength Tylenol PM active ingredients
  • Pain reliever and nighttime sleep aid
  • Non-habit forming
  • Provides temporary relief of occasional headaches and minor aches and pains with accompanying sleeplessness
  • Active ingredients: acetaminophen 500 mg, diphenhydramine HCl 25 mg
Bestseller No. 14
GenCare - Extra Strength Headache Relief Acetaminophen with Aspirin (NSAID) & Caffeine (300 Caplets)...
  • ✅ HEAD & BODY PAIN RELIEF - Each caplet of Extra Strength Headache Relief contains 250mg of Acetaminophen, 250mg of Aspirin (NSAID) and 65 mg of...
  • ✅ BULK SAVINGS - You and your family will always have effective over the counter relief with our family size 300 caplet value savings bottle. Always...
  • ✅ ACTS FAST - Headaches, migraines and pain can hit at the worst time. 65 mg of caffeine in each pill help energize you and restore mental focus so...
  • ✅ HELPS WITH ACHES & PAINS - Toothaches, menstrual cramps, arthritis, joint pain and more in one easy to swallow caplet. Adults and children 12...
  • ✅ 100% SATISFACTION GUARANTEE - Say goodbye to headaches and pain! GenCare backs up each bulk savings bottle of Extra Strength Headache Relief with...
Bestseller No. 15
Rite Aid Extra Strength 500 mg Acetaminophen Pain Relief, Rapid Release Gelcaps - 150 Count | Pain...
  • PAIN RELIEVER & FEVER REDUCER: Rite Aid Extra Strength Acetaminophen Rapid Release Gelcaps reduce fevers temporarily while offering minor headache...
  • EXTRA STRENGTH: Compare Rite Aid’s Extra Strength Acetaminophen to the active ingredient in top brands. Get all the benefits of an effective pain...
  • EASY-OPEN BOTTLE: When you need pain relief, you want a quick and easy bottle to open. Rite Aid Acetaminophen comes in an easy-open bottle that’s...
  • NO ASPIRIN: Each gelcap contains 500 mg of pain relieving, fever reducing acetaminophen without any aspirin. This aspirin-free arthritis pain relief,...
  • TRUSTED BRAND SINCE 1962: We hope you continue to choose Rite Aid first for your everyday health and wellness needs. Our mission is to improve the...
Bestseller No. 16
ValuMeds Extra Strength Headache Relief Caplets (300-Count) | Nonsteroidal Anti-Inflammatory Pain...
  • All-Over Pain Relief – This extra-strength headache medicine also helps relieve other aches and pains, such as arthritis, muscles aches, toothaches,...
  • Advanced Active Ingredients – Comparable to Excedrin Extra Strength, the ValuMeds formula contains 250mg of Acetaminophen, 250mg of Aspirin, and...
  • Quick, Reliable Relief – Our headache medicine can start providing relief in as little as 15 minutes, ideal for relieving sinus and tension...
  • Large Family Size – Each bottle of our pain relief medicine contains 300 total caplets to help you and your entire family find long-lasting relief...
  • Small Caffeine Boost – ValuMeds headache medicine contains a small amount of caffeine to help supplement your energy levels and improve your overall...
Bestseller No. 17
Amazon Basic Care Naproxen Sodium Tablets, 220 mg, 100 Count
  • STRENGTH TO LAST 12 HOURS: Pain reliever and fever reduction for up to 12 hours so you can get through the day
  • ACHES AND PAINS: Temporarily relieves minor aches and pains due to minor pain of arthritis, muscular aches, backache, menstrual cramps, headache,...
  • ALL DAY RELIEF: Amazon Basic Care Naproxen Sodium Tablets 220 mg is a pain reliever and fever reducer for adults and children age 12 years and over
  • CAPSULE-SHAPED TABLETS: This 12 hour pain reliever and fever reducer comes in a capsule-shaped tablet; this product is gluten free

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John Harvards provides an equate extra strength acetaminophen buying guide, and the information is totally objective and authentic. We employ both AI and big data in proofreading the collected information.

How did we create this buying guide? We did it using a custom-created selection of algorithms that lets us manifest a top-10 list of the best available equate extra strength acetaminophen currently available on the market.

This technology we use to assemble our list depends on a variety of factors, including but not limited to the following:

  1. Brand Value: Every brand of equate extra strength acetaminophen has a value all its own. Most brands offer some sort of unique selling proposition that’s supposed to bring something different to the table than their competitors.
  2. Features: What bells and whistles matter for an equate extra strength acetaminophen?
  3. Specifications: How powerful they are can be measured.
  4. Product Value: This simply is how much bang for the buck you get from your equate extra strength acetaminophen.
  5. Customer Ratings: Number ratings grade equate extra strength acetaminophen objectively.
  6. Customer Reviews: Closely related to ratings, these paragraphs give you first-hand and detailed information from real-world users about their equate extra strength acetaminophen.
  7. Product Quality: You don’t always get what you pay for with an equate extra strength acetaminophen, sometimes less, and sometimes more.
  8. Product Reliability: How sturdy and durable an equate extra strength acetaminophen is should be an indication of how long it will work out for you.

John Harvards always remembers that maintaining equate extra strength acetaminophen information to stay current is a top priority, which is why we are constantly updating our websites. Learn more about us using online sources.

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FAQ:

Q: Is equate pain reliever same as Tylenol?

A: YES. Tylenol (brand name) and Equate (generic) are both acetaminophen. The same doses of the same drugs are equally effective, assuming that the quality and delivery is the same. Often the drugs are even made in the same plant for many “store brand” products.

Q: Do equate stay awake pills contain amphetamine?

A: Amphetamines are stimulant drugs. They make the messages between your brain and body move faster. As a result, you are more alert and physically active. Some people use amphetamines to help them stay awake on the job or to study for a test. Others use them to boost their performance in sports. Amphetamines also cause the brain to release dopamine.

Q: Does Tylenol extra strength have any caffeine in it?

A: Tylenol 8-hour Arthritis Pain contains no caffeine, only 650 mg of acetaminophen per tablet. Regular Strength Tylenol contains 325 mg of acetaminophen per tablet. Tylenol Extra Strength Caplets contains 500 mg of acetaminophen, but also no caffeine. Learn more about TYLENOL® products | TYLENOL®

Q: How effective is Extra Strength Tylenol?

A: 92 major drug interactions (411 brand and generic names) 255 moderate drug interactions (995 brand and generic names) 14 minor drug interactions (75 brand and generic names)