20 Best Does Frontline Spray Work [2025]

Are you looking for the best Does Frontline Spray Work? Based on expert reviews, we ranked them. We've listed our top-ranked picks, including the top-selling Does Frontline Spray Work.

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# Preview Product
1 FRONTLINE Dog Spray 250mL FRONTLINE Dog Spray 250mL
2 FRONTLINE Dog Spray 500mL FRONTLINE Dog Spray 500mL
3 Adams Flea & Tick Home Spray, Kills Fleas, Flea Eggs, Flea Larvae, Bed Bugs, Ticks, Ants,... Adams Flea & Tick Home Spray, Kills Fleas, Flea Eggs, Flea Larvae, Bed Bugs, Ticks, Ants,...
4 Scrub Buddies One Pair Reusable Gloves - Medium Scrub Buddies One Pair Reusable Gloves - Medium
5 Flea and Tick Spray for Dogs & Cats Safe Humans Kids & Pet Vet's Treatment Best Pets Ticks, Fleas... Flea and Tick Spray for Dogs & Cats Safe Humans Kids & Pet Vet's Treatment Best Pets Ticks, Fleas...
6 RGB Gaming Mouse Pads ST AR15 Tactical Humanoid Mouse Pads Anime Gaming RGB Mouse Pad Girls... RGB Gaming Mouse Pads ST AR15 Tactical Humanoid Mouse Pads Anime Gaming RGB Mouse Pad Girls...
7 72 Set 16 oz Dog Puppy Theme Design Disposable Coffee Cups with Lids, Hot Paper Coffee Cup with... 72 Set 16 oz Dog Puppy Theme Design Disposable Coffee Cups with Lids, Hot Paper Coffee Cup with...
8 Setibre 68' Sprinkle & Splash Play Mat, Outdoor Water Play Toys, Sprinkler Toy Splash Play Pad with... Setibre 68" Sprinkle & Splash Play Mat, Outdoor Water Play Toys, Sprinkler Toy Splash Play Pad...
9 vpx Redline Xtreme, Watermelon, 8 Ounce Bottles, 24 Count vpx Redline Xtreme, Watermelon, 8 Ounce Bottles, 24 Count
10 Vet's Best Flea and Tick Home Spray for Cats | Flea Treatment for Cats and Home | Plant-Based... Vet's Best Flea and Tick Home Spray for Cats | Flea Treatment for Cats and Home | Plant-Based...
11 Vet’s Best Brewer’s Yeast & Garlic Chews| Healthy Skin & Coat Protection for Dogs | Formulated... Vet’s Best Brewer’s Yeast & Garlic Chews| Healthy Skin & Coat Protection for Dogs |...
12 Blue Buffalo Wilderness Trail Treats Wild Bits High Protein Grain Free Soft-Moist Training Dog... Blue Buffalo Wilderness Trail Treats Wild Bits High Protein Grain Free Soft-Moist Training Dog...
13 Activate II Flea and Tick Prevention for Dogs, XL Dogs 55+ lbs, Fast Acting Flea Drops, 8 Count Activate II Flea and Tick Prevention for Dogs, XL Dogs 55+ lbs, Fast Acting Flea Drops, 8 Count
14 PetLab Co. Itch Relief Chews - Support For Dry, Occasionally Itchy Skin & Coats - Formulated With... PetLab Co. Itch Relief Chews - Support For Dry, Occasionally Itchy Skin & Coats - Formulated With...
15 Frontline Plus Flea and Tick Treatment for Dogs (Small Dog, 5-22 Pounds, 3 Doses) Frontline Plus Flea and Tick Treatment for Dogs (Small Dog, 5-22 Pounds, 3 Doses)
16 Rodent Sheriff Pest Control - Ultra-Pure Peppermint Spray - Repels Mice, Raccoons, Ants, and More -... Rodent Sheriff Pest Control - Ultra-Pure Peppermint Spray - Repels Mice, Raccoons, Ants, and More...
17 Cutter Backyard Bug Control Spray Concentrate, Mosquito Repellent, Kills Mosquitoes, Fleas & Listed... Cutter Backyard Bug Control Spray Concentrate, Mosquito Repellent, Kills Mosquitoes, Fleas &...
18 TevraPet Activate II Flea and Tick Prevention for Extra Large Dogs over 55 pounds, 4 Monthly Doses... TevraPet Activate II Flea and Tick Prevention for Extra Large Dogs over 55 pounds, 4 Monthly...
SaleBestseller No. 1
FRONTLINE Dog Spray 250mL
  • Contains fipronil to kill existing flea and tick infestations. It also kills fleas before they lay eggs, effectively preventing reinfestation for up...
  • Kills up to 100% of existing fleas within 24 hours
  • Remains waterproof for 30 days, even if your dog or cat swims or is bathed
  • Easy to use spray bottle and is safe for use on puppies and kittens 8 weeks of age or older
  • Kills fleas at all life stages, brown dog ticks, American dog ticks, lone star ticks, and deer ticks. Also helps control flea allergy dermatitis when...
SaleBestseller No. 2
FRONTLINE Dog Spray 500mL
  • Contains fipronil to kill existing flea and tick infestations. It also kills fleas before they lay eggs, effectively preventing reinfestation for up...
  • Kills up to 100% of existing fleas within 24 hours
  • Remains waterproof for 30 days, even if your dog or cat swims or is bathed
  • Easy to use spray bottle and is safe for use on puppies and kittens 8 weeks of age or older
  • Kills fleas at all life stages, brown dog ticks, American dog ticks, lone star ticks, and deer ticks. Also helps control flea allergy dermatitis when...
Bestseller No. 3
Adams Flea & Tick Home Spray, Kills Fleas, Flea Eggs, Flea Larvae, Bed Bugs, Ticks, Ants,...
  • PROVEN EFFECTIVE - Kills fleas, flea eggs, flea larvae, bed bugs, ticks, cockroaches, ants*, spiders, mosquitoes, and many other labeled insects...
  • KILLS FAST - Begins killing fleas in as little as 5 minutes
  • DUAL ACTION - Kills over 30 insects and prevents new infestations
  • 7-MONTH PROTECTION - Provides up to 7 months of flea protection
  • COMPLETE HOME DEFENSE - Use on carpets, rugs, upholstery, and pet bedding; do not spray directly on pets
Bestseller No. 5
Flea and Tick Spray for Dogs & Cats Safe Humans Kids & Pet Vet's Treatment Best Pets Ticks, Fleas...
  • NATURAL TREATMENT: Use natural plant essential oil ingredients to kills and repel fleas and ticks, lice, mite, mosquitoes through contact. It can kill...
  • SAFE AND EFFECTIVE: It is safe for dogs and cats of all ages. It can be frequently used for puppies, kittens and senior pets as needed. It can be used...
  • Plant essential oil ingredients: Natural plant essential oil spray can effective alternative to collars, pills, chews and drops are safe alternatives.
  • Comprehensive prevention: suitable for dogs, cats and homes! kills fleas on carpets, furniture, bedding and the entire house on the floor. It can use...
  • CHARITY !!-- With every sold spray we donate 1$ to Organizations that are engaged in saving animals. Help us to give them hope! Nothing is more...
Bestseller No. 6
RGB Gaming Mouse Pads ST AR15 Tactical Humanoid Mouse Pads Anime Gaming RGB Mouse Pad Girls...
  • ☆Ultra smooth surface: enhance your computer experience, indirectly improve your game play, enjoy silky feel.
  • ☆Non-Slip Bottom: The large mouse pad is with non-slip rubber under, so that it will not move everywhere while you are during game fierce fighting,...
  • ☆Able to fold:You can roll it up and take it away, it will not be damaged or crushed.
  • ☆A variety of lighting colors: Let your every choice be full of expectations, choose the type you like, worthy of your wonderful operation.
  • ☆Durable stitched edges:Our gaming mousepad with locking edge which can make our mouse pad use longer.
Bestseller No. 7
72 Set 16 oz Dog Puppy Theme Design Disposable Coffee Cups with Lids, Hot Paper Coffee Cup with...
  • 【Leak-Free Cups】 Our sturdy to go coffee paper cups with lids are lined to prevent condensation and leaking. The coffee cups with lids 16 oz keep...
  • 【Disposable Cups with Lids】 Each to go coffee cup with lids is equipped with a matching leak-proof lid. So even if you are on the way to work, you...
  • 【Cute Puppy Design】 Paper coffee cups of 6 designs of dogs. The adorable patterns make these disposable tea cups an attractive and convenient...
  • 【Convenient&High-Quality Coffee Cup】 These disposable 16 oz coffee cups with lids are perfect to take your tea or coffee on the go, fitting in...
  • 【Perfect for Any Occasion】 These hot coffee cups nicely fit any beverage. The bulk cups are perfect for drinks such as coffee, cocoa, tea, hot...
Bestseller No. 8
Setibre 68" Sprinkle & Splash Play Mat, Outdoor Water Play Toys, Sprinkler Toy Splash Play Pad with...
  • Sprinkle & Splash Play Mat: Made of durable, soft and heavy-duty PVC material, environmental and non-toxic. Let your kids fully enjoy the fun of a...
  • Larger for More Fun: This inflatable play mat measures 68" in diameter with gentle water sprays come from the squishy water-filled border and fill the...
  • Best Summer Water Toys: Featured an attractive design that your water-lover will enjoy, “From A to Z” splash pool features cute animals and the...
  • Easy to Set Up: Just plug it to a garden hose and you can adjust the pressure to easily control water splash heights. All the water will be pool in...
  • Are you looking for a fun way for your kids to cool off this summer? Setibre sprinkle and splash pad is the perfect way to introduce your child to...
SaleBestseller No. 9
vpx Redline Xtreme, Watermelon, 8 Ounce Bottles, 24 Count
  • The Front Runner in Sports Nutrition
  • Makers of BANG; Redline; and Shotgun!
  • Item Package Dimension: 15.494cm L x 21.844cm W x 33.528cm H
  • Item Package Weight: 6.736kg
SaleBestseller No. 10
Vet's Best Flea and Tick Home Spray for Cats | Flea Treatment for Cats and Home | Plant-Based...
  • JUST FOR CATS - Vet’s Best Flea and Tick Home Spray for Cats is formulated with cats in mind and kills fleas, flea larvae, flea eggs, and ticks by...
  • PROVEN EFFECTIVE - Whether facing an active infestation or are applying for routine prevention, Vet's Best Home Spray for Cats is scientifically...
  • CERTIFIED NATURAL OILS - Each steam-distilled essential oil is selected for its potent pest-fighting properties and is 100% Certified Natural.
  • TOTAL HOME DEFENSE - Applies easily on cat furniture, crates, pillows, blankets, upholstery, carpets, outdoor surfaces, and more. Also gentle enough...
  • MADE IN THE USA: Our products are proudly manufactured in the USA with quality domestic and internationally sourced ingredients.
SaleBestseller No. 11
Vet’s Best Brewer’s Yeast & Garlic Chews| Healthy Skin & Coat Protection for Dogs | Formulated...
  • SKIN & COAT HEALTH – Helps support healthy skin & coat while maintaining normal levels of shedding without the use of harsh ingredients.
  • HEALTHY IMMUNE SYSTEM – Naturally occurring antioxidant properties that support the immune system and normal digestion.
  • ESSENTIAL FATTY ACIDS - Omega 3, 6, and 9 Fatty Acids help support a glossy coat and healthy skin.
  • NATURAL INGREDIENTS – Contains natural ingredients sourced in the United States: Brewer’s Yeast, Apple Cider Vinegar and Garlic.
  • HEALTHY INGREDIENT DOSE - Veterinarian formulated with just the right amount of garlic. Each soft chew contains a healthy and safe dose of less than...
Bestseller No. 12
Blue Buffalo Wilderness Trail Treats Wild Bits High Protein Grain Free Soft-Moist Training Dog...
  • PACKED WITH REAL MEAT: Made with more of the delicious salmon or chicken your dog loves, BLUE Wilderness Wild Bits are the soft-moist and meaty treat...
  • MADE WITH DHA: An important fatty acid found in mother’s milk, DHA helps promote cognitive development in canines
  • WHOLESOME INGREDIENTS: Made with omega 3 & 6 fatty acids, these dog training treats are more than just tasty, they’re healthy too!
  • GRAIN FREE DOG TREATS: Featuring only the finest natural ingredients enhanced with vitamins and minerals, Wilderness dog treats are grain free and...
  • BUNDLE: Contains two (2) 10-oz bags of BLUE Wilderness Trail Treats Wild Bits High Protein Grain Free Soft-Moist Training Dog Treats, Salmon Recipe or...
Bestseller No. 13
Activate II Flea and Tick Prevention for Dogs, XL Dogs 55+ lbs, Fast Acting Flea Drops, 8 Count
  • COMPARE TO K9 ADVANTIX II: Activate II uses Imidacloprid, Permethrin, and Pyriproxyfen - the same safe, fast acting active ingredients used in...
  • ACTIVELY PROTECTS YOUR DOG: Activate II is approved by veterinarians to repel and kill fleas and ticks on contact - before your dog is exposed to...
  • STOP INFESTATIONS FAST: Our topical drops prevent infestations by breaking the flea life cycle - our insect growth regulator (IGR) starts killing flea...
  • EASY TO APPLY: Simply apply to the base of your dog's neck, and the waterproof solution will travel across the skin - providing continuous protection...
  • MADE IN AMERICA - RESULTS GUARANTEED: TevraPet Activate II is made to the quality standard we demand for our own pets. We're proud to help you protect...
Bestseller No. 14
PetLab Co. Itch Relief Chews - Support For Dry, Occasionally Itchy Skin & Coats - Formulated With...
  • COAT CONDITION & COMFORT - These skin support and dog seasonal allergy chews promote healthy coats and soothe occasionally dry, or irritated skin
  • WORLD-CLASS FORMULA - Itch Relief Chews contain a stellar formula comprised of omega-rich oils like Salmon and Flaxseed oil, as well as Tumeric,...
  • FUSS FREE - Giving your pup beneficial dog supplements is a breeze with PetLab Co. Our Itch Relief Chews are infused with a delicious pork flavor,...
  • PREMIUM PRODUCTS - Our dog health supplies are made using high-quality ingredients from the US and prime locations worldwide, and our products are...
  • INVEST IN YOUR DOG’S HEALTH - Support a healthy, happy, and comfortable life for your dog with our Itch Relief Chews. Join over 1 million dogs and...
SaleBestseller No. 15
Frontline Plus Flea and Tick Treatment for Dogs (Small Dog, 5-22 Pounds, 3 Doses)
  • Waterproof flea and tick treatment for dogs: Frontline Plus for Dogs provides waterproof, fast-acting, long-lasting flea and tick treatment and...
  • Break the flea life cycle with frontline: Frontline flea and tick treatment for dogs kills adult fleas plus flea eggs and larvae to stop existing...
  • Kills fleas and ticks: Frontline flea and tick treatment for dogs kills fleas, flea eggs, lice, and ticks. This flea and tick treatment kills ticks,...
  • Trusted flea and tick protection for dogs: Frontline has been trusted by veterinarians for nearly 20 years. Made with 2 tough killing ingredients,...
  • Lasting flea and tick protection: Frontline's long-lasting formula isstored in the oil glands of the pet’s skin to give non-stop flea and tick...
SaleBestseller No. 16
Rodent Sheriff Pest Control - Ultra-Pure Peppermint Spray - Repels Mice, Raccoons, Ants, and More -...
  • Made with all-natural peppermint oil, SAFE to use around pets and children but rodents hate it! Non toxic - MADE IN AMERICA
  • Safe to spray in your home or garden. Rodents naturally dislike the smell of this handcrafted peppermint formula and will repel pests almost...
  • Proven to repel mice, raccoons, roaches, insects & more
  • Contains two 8 ounce bottles of all-natural peppermint power - Enough for 2,000 sprays.
  • Use anywhere that's prone to pests - Garages, basements, kitchens, attics, sheds, trash cans, & more. Intended for indoor and outdoor use
SaleBestseller No. 17
Cutter Backyard Bug Control Spray Concentrate, Mosquito Repellent, Kills Mosquitoes, Fleas & Listed...
  • KILLS FAST: Kills mosquitoes, listed ant types, fleas and other listed insects
  • QUICKFLIP HOSE-END SPRAYER: Hose-end-sprayer activates spray at the flip of a switch – just grip, flip and go
  • LASTS ALL SUMMER: Controls up to 12 weeks against house crickets, carpenter ants, harvester ants, lady beetles and earwigs
  • COVERAGE: Treats up to 5,000 square feet of lawn
  • NO MIXING REQUIRED: Attach the sprayer to a garden hose to treat your lawn, landscape and outdoor surfaces where insects hide
SaleBestseller No. 18
TevraPet Activate II Flea and Tick Prevention for Extra Large Dogs over 55 pounds, 4 Monthly Doses...
  • Compare to K9 Advantix: Activate II uses Imidacloprid, Permethrin, and Pyriproxyfen - the same safe, fast acting active ingredients used in Advantix...
  • Flea, tick, and mosquito protection: Activate II is approved by veterinarians to repel and kill fleas and ticks on contact - before your dog is...
  • Break the flea lifecycle FAST: Our topical drops stop and control infestations - our insect growth regulator (IGR) starts killing flea eggs and larvae...
  • Easy to apply, continuous prevention: Simply apply to the base of your dog's neck, and the waterproof solution will travel across the skin - providing...
  • Made in America, results guaranteed: TevraPet Activate II is made to the exacting standards we demand for our own pets. We're proud to help you...

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FAQ:

Q: Can you use a flea spray with Frontline?

A: To start fighting the home infestation straight away, you can also use FRONTLINE ® HomeGard household spray. It kills fleas and larvae, and also prevent eggs and larvae from developing in your home for up to 12 months.

Q: Is it safe to use frontline on a human?

A: Is it safe to use Frontline on a human? No, as a rule, do not use products meant for animals on yourself. As Kerry Krueger said, it could cause cancer and disrupt the endocrine system. Also, you do not need it and it would not work because human and dog physiology is very different. You, a human, cannot get “infested” with fleas like dogs do.

Q: Does frontline wash off?

A: can Frontline be washed off? Otherwise there is absolutely no way to get Frontline off the dog – and absolutely no necessity either, unless you are planning to let your T’s walk all over the dog. Exactly, just give the dog a bath, and wash the applied area with dawn. The applied area is generally between the dog’s shoulder blades.

Q: Does frontline repel ticks?

A: Frontline kills ticks within 24 to 48 hrs of contact. It does not repel ticks or fleas from clinging onto your pet. But since it kills the parasite very quickly, it prevents infestation.