20 Best Cold Sore Supplement [2025]

Are you looking for the best cold sore supplement? Based on expert reviews, we ranked them. We've listed our top-ranked picks, including the top-selling cold sore supplement.

We Recommended:

# Preview Product
1 COLD SORE SHIELD Daily Cold Sore Defense Supplement. Immune Support Lip Blister & Cold Sore... COLD SORE SHIELD Daily Cold Sore Defense Supplement. Immune Support Lip Blister & Cold Sore...
2 Quantum Health Super Lysine+ / Advanced Formula Lysine+ Immune Support with Vitamin C, Echinacea,... Quantum Health Super Lysine+ / Advanced Formula Lysine+ Immune Support with Vitamin C, Echinacea,...
3 Best Cold Sore Supplement with Lysine and Lemon Balm - Dr. Danielle Cold Sore Assist - 120 Capsules Best Cold Sore Supplement with Lysine and Lemon Balm - Dr. Danielle Cold Sore Assist - 120 Capsules
4 Premium Immune Support - HRP-Aid - Prodigy Life Cold Sore Medicine - Lysine Complex with Vitamin C,... Premium Immune Support - HRP-Aid - Prodigy Life Cold Sore Medicine - Lysine Complex with Vitamin...
5 Herp Plus Cold Sore Shingles Vitamins Herpes Supplements Medicine Clinical Strength L-lysine Olive... Herp Plus Cold Sore Shingles Vitamins Herpes Supplements Medicine Clinical Strength L-lysine...
6 Clear Probiotics Lip and Skin Health - Cold Sore Blister Defense - Probiotic + Prebiotic - Lysine -... Clear Probiotics Lip and Skin Health - Cold Sore Blister Defense - Probiotic + Prebiotic - Lysine...
7 LIP+GUARD 1000mg L-Lysine Cold Sore Supplements - Fast-Acting Vitamin C & D, Olive Leaf Extract... LIP+GUARD 1000mg L-Lysine Cold Sore Supplements - Fast-Acting Vitamin C & D, Olive Leaf Extract...
8 Lysine Capsules for Great Mouth and Lip Health, Natural Immune Booster with L-Lysine and Vitamin C,... Lysine Capsules for Great Mouth and Lip Health, Natural Immune Booster with L-Lysine and Vitamin...
9 Best Naturals L-Lysine 1000mg 180 Tablets - Double Strength Lysine for stronger immune health & cold... Best Naturals L-Lysine 1000mg 180 Tablets - Double Strength Lysine for stronger immune health &...
10 Bravado Labs Premium Herpees Supplement - Outbreak Support with Super Lysine - Immune Support... Bravado Labs Premium Herpees Supplement - Outbreak Support with Super Lysine - Immune Support...
11 Designs for Health L-Lysine HCL Pills 1500mg - Amino Acid Lysine Hydrochloride Nutritional... Designs for Health L-Lysine HCL Pills 1500mg - Amino Acid Lysine Hydrochloride Nutritional...
12 NOW Supplements, L-Lysine (L-Lysine Hydrochloride) 500 mg, Amino Acid, 250 Tablets NOW Supplements, L-Lysine (L-Lysine Hydrochloride) 500 mg, Amino Acid, 250 Tablets
13 DALINEX Cold Sore Treatment - Eliminates Cold Sores and Minimizes Outbreaks, Strengthens Immune... DALINEX Cold Sore Treatment - Eliminates Cold Sores and Minimizes Outbreaks, Strengthens Immune...
14 Natural Cure Labs Clean L-Lysine 600mg, 120 Capsules Natural Cure Labs Clean L-Lysine 600mg, 120 Capsules
15 BRI Nutrition L-Lysine 180 Servings Per Bottle - Super 500mg Veggie Capsules BRI Nutrition L-Lysine 180 Servings Per Bottle - Super 500mg Veggie Capsules
16 The Good Doctor's Guide to Colds and Flu [Updated Edition]: How to Prevent and Treat Colds, Flu,... The Good Doctor's Guide to Colds and Flu [Updated Edition]: How to Prevent and Treat Colds, Flu,...
17 Lip Balm Stocking Stuffer, Burt's Bees Moisturizing Lip Care Holiday Gift, 100% Natural, SuperFruit... Lip Balm Stocking Stuffer, Burt's Bees Moisturizing Lip Care Holiday Gift, 100% Natural,...
18 Bronson L-Lysine Defense Immune Support Complex 1500 MG L-Lysine Plus Olive Leaf, Garlic, Vitamin C... Bronson L-Lysine Defense Immune Support Complex 1500 MG L-Lysine Plus Olive Leaf, Garlic, Vitamin...
19 Amazon Elements Lysine Complex with Vitamin C, 1500 mg L-Lysine with 100 mg Vitamin C per Serving (3... Amazon Elements Lysine Complex with Vitamin C, 1500 mg L-Lysine with 100 mg Vitamin C per Serving...
20 Immune Support Formula (H Rescue Discreet) Immune Support Supplement L Lysine, Zinc, Vitamin C,... Immune Support Formula (H Rescue Discreet) Immune Support Supplement L Lysine, Zinc, Vitamin C,...
Bestseller No. 1
COLD SORE SHIELD Daily Cold Sore Defense Supplement. Immune Support Lip Blister & Cold Sore...
  • NO MORE EMBARRASSING COLD SORES: Our cold sore defence helps you no longer live in fear of embarrassing cold sores and surprise breakouts. Take daily...
  • POWERFUL INGREDIENTS: Combination of potent immune supporting nutrients including zinc, selenium, vitamin C, L lysine and more. All made and...
  • IMMUNE SYSTEM BOOST: Cold sore shield's cold sore treatment works with the body's immune system to support its daily defense of cold sores*
  • DAILY SUPPLEMENT: Taken daily, or just weeks before a stressful event, important date, travel etc, Cold Sore Shield helps the defence of cold sore...
  • BUY WITH CONFIDENCE: Buy our cold sore defense product worry free! Don’t LOVE them? Simply return them!
SaleBestseller No. 2
Quantum Health Super Lysine+ / Advanced Formula Lysine+ Immune Support with Vitamin C, Echinacea,...
  • ADVANCED L-LYSINE IMMUNE BOOST - Super Lysine+ provides L-Lysine, Vitamin C, deodorized garlic, and Echinacea for immune support and lip health, plus...
  • Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product...
  • THE MANY BENEFITS OF LYSINE - A building block of protein, Lysine benefits include immune system support, promoting collagen growth, & supporting lip...
  • AWARD-WINNING LYSINE POWER FORMULA - Taste for Life Immunity Essentials Specialty Award (2015), Taste for Life Supplement Essentials Award (2013), and...
  • FROM A TRUSTED LEADER IN THE NATURAL PRODUCTS INDUSTRY – Quantum Health's first product was a Lysine cold sore treatment. Since then, Quantum Health...
Bestseller No. 3
Best Cold Sore Supplement with Lysine and Lemon Balm - Dr. Danielle Cold Sore Assist - 120 Capsules
  • BEST COLD SORE SUPPLEMENT - Effective support both before and during out breaks.
  • L-LYSINE - Lycine is one of nature’s secret weapons that is well known for helping cold sores sufferers. Lysine impedes the activity of arginine, an...
  • BEST ORGANIC INGREDIENTS FOR COLD SORES- ORGANIC Lemon Balm Extract is great for early stage care when suffering from an break out. This formula also...
  • MONOLAURIN - Aids your body in maintaining a healthy balance, which helps you mount a strong immune defense.
  • ZINC, ELDERBERRY, PROPOLIS - Give your body and immune system the support it needs to combat cold sores.
Bestseller No. 4
Premium Immune Support - HRP-Aid - Prodigy Life Cold Sore Medicine - Lysine Complex with Vitamin C,...
  • Ultra Potent: The Most Effective Support For Outbreaks. Get A Supplement That Works.
  • Boost Your Immune System: Provides The Ingredients Your Body Needs For A Stronger Immune Response. The Result Is Fewer Outbreaks At Lesser Intensity.
  • Speeds Up Responses: Faster Recovery Means Less Days Of Suffering. Taking This Product Daily May Prevent Outbreaks From Occurring.
  • Total Holistic Support: With L-lysine, Zinc, Vitamin C, Vitamin B6, Vitamin E, Vitamin B12, Vitamin D3, Ginseng, Selenium, Echinacea, Astragalus,...
  • Guaranteed: Prodigy Life Offers A No questions asked Money Back Guarantee. If You're Dissatisfied For Any Reason, Simply Contact Us For A Full Refund.
Bestseller No. 5
Herp Plus Cold Sore Shingles Vitamins Herpes Supplements Medicine Clinical Strength L-lysine Olive...
  • STRONGEST OTC FORMULA COLD Sore MEDICATION BEST RATINGS because it WORKS, Groundbreaking to help you get control of Cold sores loaded with cold sore...
  • MOST COMPLETE immune support formula for cold sore relief shingles relief herps. Don't wear a cold sore patch, prevent it form within. Herpes...
  • MAX High-dose vitamin B12 ,Vitamin C, L - lysine, Vitamin E, Vitamin A, and Zinc all vital ingredients great cold sore remedy
  • MAXIMUM Relief Research has found that the herb OLIVE LEAF EXTRACTS and Prunella vulgaris are key
  • Proprietary blend of botanical. PANCREATIN enzymes are helpful cold+sore+medicine
Bestseller No. 6
Clear Probiotics Lip and Skin Health - Cold Sore Blister Defense - Probiotic + Prebiotic - Lysine -...
  • FORMULATED FOR HEALTHY, BEAUTIFUL LIPS - Clear Probiotics Lip and Skin is specially formulated probiotic blend, along with key ingredients like lysine...
  • CLEAR LIPS AND SKIN START IN THE GUT - Did you know that cold sores and blisters around your mouth can the result of a bacterial imbalance in your...
  • IMPROVE YOUR GUT HEALTH AND MICROBIOME -Clear Probiotics Lip and Skin Health promotes healthy, clear lips and skin and GI tract health. Ease bloating...
  • POWERFUL INGREDIENTS TO FIGHT OUTBREAKS - Our powerful formula contains key ingredients like vitamin C and lysine which are designed to improve immune...
  • CLEAR PROBIOTICS ARE CLEAR FOR A REASON - Clear probiotics is named so for its transparency in their formulas and ingredients. No proprietary blends,...
Bestseller No. 7
LIP+GUARD 1000mg L-Lysine Cold Sore Supplements - Fast-Acting Vitamin C & D, Olive Leaf Extract...
  • COLD SORE ENEMY #1: At My Beach Shop, we HATE cold sores from the initial tenderness and tingle to the days and nights of pain and embarrassment. The...
  • ALL-IN-ONE LYSINE SUPPLEMENT – Fortified with natural extracts and a rich blend of vitamins C, D, B6, and B12 these L-Lysine capsules act as a...
  • KISS COLD SORES GOODBYE WITH LIP+GUARD: Lets be honest, Cold Sores suck! They affect relationships, our careers and even our happiness. They also keep...
  • LIP BLISTER RELIEF WITH YEAR-ROUND IMMUNE SUPPORT - NATURAL REMEDY YOU CAN FEEL! A premium immune support formula Lip+Guard helps nourish your immune...
  • OUR NO HASSLE, NO STRINGS ATTACHED GUARANTEE: At My Beach Shop, your health and wellbeing is our #1 concern. We are so certain that you will Love...
Bestseller No. 8
Lysine Capsules for Great Mouth and Lip Health, Natural Immune Booster with L-Lysine and Vitamin C,...
  • Helps Lips Against Cold Sores - A weak immune system may cause painful cold sores. To keep them at bay, get optimum immune support with Clearlips...
  • Promotes Wound Healing - With an improved immune system and collagen production, cold sores can heal faster. Lysine is required for the formation of...
  • Unique, Natural Blend - Our lysine capsules contain a special yet natural blend of L-Lysine, Vitamin C, Vitamin B12, Biotin, Zinc, and Echinacea to...
  • Reduces Stress - Formulated by US dentists, our Clearlips lysine capsules may also help ease tension by blocking stress response receptors.
  • Easy-to-Take - No more pricey treatments, topical creams, patches, and gels! Taking 2 capsules a day is all you need to maintain a healthy mouth and...
Bestseller No. 9
Best Naturals L-Lysine 1000mg 180 Tablets - Double Strength Lysine for stronger immune health & cold...
  • 3rd Party Lab Tested for Purity & Quality.
  • 1000 mg of L-Lysine HCL per Tablet - 180 Tablets per Bottle.
  • Non-GMO & Gluten-Free.
  • Proudly Made in USA, GMP Compliant, FDA Registered Facility.
  • No Artificial Color, Flavor, or Sweetener, No Preservatives, No Sugar, No Milk, No Corn, No Soy, No Egg, No Lactose, No Gluten, No Wheat, No Yeast, No...
Bestseller No. 10
Bravado Labs Premium Herpees Supplement - Outbreak Support with Super Lysine - Immune Support...
  • MAXIMUM POTENCY Our processes ensure purity and our formulations are engineered for maximum absorption.
  • IMMUNE BOOST HrpRX works to help improve your immune system. This means less outbreaks and lower intensity when outbreaks do occur. Get an immune...
  • FASTER RESPONSE to outbreaks, so you recover faster. Daily usage may prevent outbreaks completely.
  • FORTIFIED with Zinc, Vitamins C, D3, E, B6 and B12, L-Lysine, Selenium, Ginseng, Astragalus, Echinacea, Elderberry, Garlic, Green Tea, Olive and...
  • GUARANTEED to help fight your outbreaks. If you're dissatisfied, just contact us within 30 days for a full refund.
Bestseller No. 11
Designs for Health L-Lysine HCL Pills 1500mg - Amino Acid Lysine Hydrochloride Nutritional...
  • MUSCLE MAINTENANCE - Consuming adequate amounts of lysine may be difficult for individuals with certain needs or dietary restrictions, such as...
  • TISSUE & COLLAGEN SUPPORT - Lysine is necessary for healthy tissue repair and the formation of collagen, a substance critical for bones and connective...
  • QUICK ABSORPTION - This product offers lysine in the free-form, meaning it is immediately available for absorption and can be put to metabolic use...
  • HIGHER STANDARDS. BETTER RESULTS - Designs for Health maintains a strict, no-compromises approach to quality raw material selection. We never cut...
  • OVER 50,000 DOCTORS AGREE - Designs for Health is the physician's choice for top quality professional strength supplements since 1989. Our "Science...
SaleBestseller No. 12
NOW Supplements, L-Lysine (L-Lysine Hydrochloride) 500 mg, Amino Acid, 250 Tablets
  • ESSENTIAL AMINO ACID: L-Lysine is an essential amino acid, which means that it cannot be manufactured by the body and must be obtained through the...
  • SUPPORTS HEALTHY CONNECTIVE TISSUE AND CALCIUM ABSORPTION: Lysine is necessary for the production of all protein in the body including hormones,...
  • CLASSIFICATIONS/CERTIFICATIONS: Non-GMO, Dairy Free, Egg Free, Made without Gluten, Nut Free, Soy Free, Vegan/Vegetarian
  • GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our...
  • Packaged in the USA by a family owned and operated company since 1968
Bestseller No. 13
DALINEX Cold Sore Treatment - Eliminates Cold Sores and Minimizes Outbreaks, Strengthens Immune...
  • TREATS COLD SORES - Dalinex minimizes the frequency and severity of cold sores and herpes outbreaks. Our formula also boosts the immune system and...
  • POWERFUL FORMULA – Our unique blend of powerful organic elements is a natural formula that works immediately to eliminate cold sores. Customers...
  • 90-DAY MONEY BACK GUARANTEE – We think Dalinex is a terrific product but if you aren’t satisfied with your purchase, please contact our customer...
  • HOW TO USE - Unscrew the cap and fill the dropper tip with a full dose of Dalinex. Empty the dropper tip into a beverage of your choice and stir....
  • LIQUID EXTRACT - Dalinex is the only treatment for cold sores and herpes outbreaks that is taken in liquid form. This delivery system gets our formula...
Bestseller No. 14
Natural Cure Labs Clean L-Lysine 600mg, 120 Capsules
  • 600mg of pure L-Lysine per capsule - the cleanest formula available
  • Award-Winning: "Company of the Year", "Product Exec of the Year", "Best Multivitamin"
  • Pure Formula: Vegan, Non-GMO, Gluten Free
  • Clean Label: No Magnesium Stearate, Silica or Dioxide
  • Quality: USA formulated, blended, and bottled
Bestseller No. 15
BRI Nutrition L-Lysine 180 Servings Per Bottle - Super 500mg Veggie Capsules
  • ★WHY US: We looked at all other Lysine supplements on the market and were surprised by how huge they were and how little other companies actually...
  • ★HOW IT WORKS: L-Lysine is an essential amino acid that cannot be made by your body and is important to the health and integrity of your skin and...
  • ★PURITY: We use only the finest ingredients, all of which are manufactured in our US, GMP compliant, state-of-the-art, facility.We're so confident...
  • ★COMMON NAMES: L-Lysine can be misspelled in numerous ways. You may see some of these around: l-lysine, lisina, llysine, lyasin, and even lycene.
  • ★SHARE: Consider ordering one bottle for yourself and another for a friend or loved one. Keep each other motivated and reach your goals together and...
Bestseller No. 16
The Good Doctor's Guide to Colds and Flu [Updated Edition]: How to Prevent and Treat Colds, Flu,...
  • Amazon Kindle Edition
  • Schachter, Neil (Author)
  • English (Publication Language)
  • 312 Pages - 02/02/2021 (Publication Date) - Harper Paperbacks (Publisher)
SaleBestseller No. 17
Lip Balm Stocking Stuffer, Burt's Bees Moisturizing Lip Care Holiday Gift, 100% Natural, SuperFruit...
  • LIP CARE: Bursting with all natural flavors, refresh and renew your lips with Burt's Bees Moisturizing Lip Balm in four naturally nourishing flavors:...
  • TOTAL HYDRATION: With beeswax and fruit extracts packed into every tube of our lip balm, you can hydrate and smooth dry lips with a quick swipe of our...
  • LONG LASTING MOISTURE: Just one swipe of our conditioning lip balm locks in moisture to leave your lips feeling conditioned and refreshed all day...
  • ALL NATURAL: Enriched with 100% natural origin ingredients, you can rest assured that the balm touching your lips will keep you glowing on the inside...
  • VALUE 4 PACK: No matter what pop of fruity flavor you are craving, this pack provides you with a lip balm for you everywhere you go. Keep one at home...
SaleBestseller No. 18
Bronson L-Lysine Defense Immune Support Complex 1500 MG L-Lysine Plus Olive Leaf, Garlic, Vitamin C...
  • L-Lysine Defense Complex: L-Lysine is an essential amino acid that is obtained through foods and supplementation. It’s thought that L-Lysine helps...
  • Plus Olive Leaf, Garlic, Vitamin C & Zinc: L-Lysine combined with key additional immune support ingredients for superior coverage. Combining natural...
  • Highest Quality Formula: Laboratory tested NON-GMO. All Bronson products are tested in our state-of-the-art cGMP registered facility in New York.
  • Trusted Since 1960: The pioneers of Bronson Vitamins were a group of pharmacists who witnessed the benefits of vitamins and mineral supplementation...
Bestseller No. 19
Amazon Elements Lysine Complex with Vitamin C, 1500 mg L-Lysine with 100 mg Vitamin C per Serving (3...
  • Lysine Complex with vitamin C, echinacea, and a variety of harvested ingredients, Supports Immune Health*
  • Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product...
  • 195 tablets, a 2 month supply (taken at the listed serving size of 3 tablets daily)
  • Vegetarian, gluten free, contains bee propolis; no artificial colors, flavors or chemical preservatives
  • Good to Know: You may notice a slight to moderate smell that is similar to tree sap, the odor is coming from the Bee propolis
Bestseller No. 20
Immune Support Formula (H Rescue Discreet) Immune Support Supplement L Lysine, Zinc, Vitamin C,...
  • Supports the Immune System
  • 100% ALL NATURAL maximum strength immune support supplement.
  • Pure ingredients of Lysine, Vitamin C, Zinc, Oregano Oil, Prunella Vulgaris, Red Marine Algae, Bee Propolis, and Olive Leaf Extract
  • Manufactured in a GMP compliant approved facility in the USA

Having trouble finding a great cold sore supplement?

This problem is well understood by us because we have gone through the entire cold sore supplement research process ourselves, which is why we have put together a comprehensive list of the best cold sore supplements available in the market today.

After hours of searching and using all the models on the market, we have found the best cold sore supplement for 2023. See our ranking below!

How Do You Buy The Best Cold Sore Supplement?

Do you get stressed out thinking about shopping for a great cold sore supplement? Do doubts keep creeping into your mind?

We understand, because we’ve already gone through the whole process of researching cold sore supplement, which is why we have assembled a comprehensive list of the greatest cold sore supplement available in the current market. We’ve also come up with a list of questions that you probably have yourself.

John Harvards has done the best we can with our thoughts and recommendations, but it’s still crucial that you do thorough research on your own for cold sore supplement that you consider buying. Your questions might include the following:

  • Is it worth buying an cold sore supplement?
  • What benefits are there with buying an cold sore supplement?
  • What factors deserve consideration when shopping for an effective cold sore supplement?
  • Why is it crucial to invest in any cold sore supplement, much less the best one?
  • Which cold sore supplement are good in the current market?
  • Where can you find information like this about cold sore supplement?

We’re convinced that you likely have far more questions than just these regarding cold sore supplement, and the only real way to satisfy your need for knowledge is to get information from as many reputable online sources as you possibly can.

Potential sources can include buying guides for cold sore supplement, rating websites, word-of-mouth testimonials, online forums, and product reviews. Thorough and mindful research is crucial to making sure you get your hands on the best-possible cold sore supplement. Make sure that you are only using trustworthy and credible websites and sources.

John Harvards provides an cold sore supplement buying guide, and the information is totally objective and authentic. We employ both AI and big data in proofreading the collected information.

How did we create this buying guide? We did it using a custom-created selection of algorithms that lets us manifest a top-10 list of the best available cold sore supplement currently available on the market.

This technology we use to assemble our list depends on a variety of factors, including but not limited to the following:

  1. Brand Value: Every brand of cold sore supplement has a value all its own. Most brands offer some sort of unique selling proposition that’s supposed to bring something different to the table than their competitors.
  2. Features: What bells and whistles matter for an cold sore supplement?
  3. Specifications: How powerful they are can be measured.
  4. Product Value: This simply is how much bang for the buck you get from your cold sore supplement.
  5. Customer Ratings: Number ratings grade cold sore supplement objectively.
  6. Customer Reviews: Closely related to ratings, these paragraphs give you first-hand and detailed information from real-world users about their cold sore supplement.
  7. Product Quality: You don’t always get what you pay for with an cold sore supplement, sometimes less, and sometimes more.
  8. Product Reliability: How sturdy and durable an cold sore supplement is should be an indication of how long it will work out for you.

John Harvards always remembers that maintaining cold sore supplement information to stay current is a top priority, which is why we are constantly updating our websites. Learn more about us using online sources.

If you think that anything we present here regarding cold sore supplement is irrelevant, incorrect, misleading, or erroneous, then please let us know promptly!

Related Post:

FAQ:

Q: What pills are good for cold sores?

A: Acyclovir Worked for Cold Sores! … Combination Approach to Combat Cold Sores: I’d like to share my approach to cold sores. … Valacyclovir Pills vs Zovirax Cream: I have had cold sores for years,generally when I’ve been stressed. … Home Remedies to Conquer Cold Sores: People who have recurrent cold sores may be miserable. …

Q: What is the most effective treatment for a cold sore?

A: – Don’t touch the cold sore. Resist the urge to pick at any crusted skin or blisters while suffering from a cold sore. … – Try ice. Cold sore sufferers often describe a cold sore as feeling inflamed. … – Throw out lip products. … – Don’t share items. … – Wash your hands. …

Q: How can I get rid of cold sores quickly?

A: Keep your lips protected from the sun at all times. Getting too much sun can irritate your skin and could cause a cold sore to pop up. Avoid sharing items or kissing to stop the spread of the virus. Cold sores are caused by the herpes simplex virus,and it usually spreads through bodily fluids. Avoid cold sore triggers. … Practice stress relief. …

Q: What is the best over the counter for cold sores?

A: – Famvir (famciclovir) – Valtrex (valacyclovir) – Acyclovir (Zovirax)